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Cognition, Action, and sensorimotor plasticity

Cerebral plasticity and BDNF

The mature form of BDNF (Brain-Derived Neurotrophic Factor) plays an essential role in promoting cerebral plasticity induced either by stroke, physical exercise or a combination of both situations. Mainly synthesized by neurons, BDNF is produced as pre-proBDNF that is cleaved into proBDNF and then mBDNF (mature BDNF). Some studies suggest that pro-BDNF and mBDNF are both secreted by neurons. Once secreted, pro-BDNF can be transformed into mBDNF and induce plastic changes through activation of TrKB receptors. Alternatively, extracellular pro-BDNF can activate P75 receptor resulting in cell death. However, this ambivalent role for BDNF has been shown from studies using neuronal cultures and hippocampal slices. The in vivo metabolism of BDNF is currently unknown, is it modified by stroke or exercise? Answering this question is the objective of our laboratory. The results will help to better understand the biochemical mechanisms underlying brain plasticity and in turn to elaborate new pharmacological strategies of post-stroke deficit.

  • BDNF and stroke
  • BDNF, neurovascular unit and exercise
  • Rehabilitation by exercise after stroke
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Université de Bourgogne