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Cognition, Action, and sensorimotor plasticity


Title: Action Preparation in the Isolated Cerebral Hemispheres: Callosal Agenesis


  • Prof. Charalambos Papaxanthis (CAPS INSERM 1093) & Prof.
  • Richard Ivry (University of California, Berkeley)

This collaboration aims to promote scientific development in the domain of motor neuroscience. The two laboratories have a shared interest in how people plan and control movement, seeing this as a model system for understanding the interface of cognition and action. In this project, we plan to investigate the neural mechanisms engaged during preparation and performance of actual and imagined movements in healthy individuals and in patients with agenesis of the corpus callosum (ACC), a rare patient group in which the direct connections between the two cerebral hemispheres are absent from birth. Transcranial magnetic stimulation (TMS), a non-invasive and safe brain stimulation technique, will be used to assess excitatory and inhibitory circuits in the cerebral hemispheres during a motor decision task.

The first set of experiments will be conducted in the ‘Cognition, Action et Plasticité Sensorimotrice’ laboratory at the University of Burgundy. Guided by this work, a second set of experiments will be conducted in the Cognition and Action Laboratory at UC Berkeley. The research group also involves an assistant professor, Dr. Florent Lebon, at the INSERM laboratory of the University of Burgundy and a research scientist, Dr. Ludovica Labruna, at the Cognition and Action Laboratory at UC Berkeley. Dr. Lebon and Dr. Labruna will contribute to the project by programming the experiment, supervising data collection, conducting the statistical analysis, and taking a lead role in manuscript writing. This collaboration will facilitate the exchange of knowledge and skills between the two institutions and will provide an opportunity to promote a long-term relationship between the two research groups.

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Université de Bourgogne