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Cognition, Action, and sensorimotor plasticity

Elizabeth Thomas

Elizabeth Thomas email elizabeth.thomas{[at]} adresse Laboratoire INSERM U1093
Université de Bourgogne
Institut Marey, Maison de la Métalurgie
64 rue de Sully
21000 Dijon
telephone +33 3 80 39 67 84
fax +33 3 80 39 67 49
bureau Room n°207


2013 – L’Habilitation à Diriger les Recherches get pdf
Title: Computational Neuroscience : From Network to Behavior
Committee Members : Alain Destexhe, Michel Paindavoine, Thierry Pozzo, Stephane Swinnen, Simon Thorpe, Krasimira Tsaneva-Atanasova
2002 – Equivalent PhD in Biomedical Sciences : Docteur en Sciences Biomédicales, Université de Liége, Belgium.
1993 - Ph.D. in Chemistry, University of Texas, Austin, U.S.A.
Title : Investigation of Dynamic and Static Aspects of a Thalamocortical Simulation
1987 – Bachelor’s in Chemistry (summa cum laude), St. John's University, New York


Current Research

I am currently carrying out computational and experimental work on the neuromuscular system. I have the following projects underway:

1) A study on muscular synergies during motor control that permit a reduction in the number of degrees of freedom involved when executing a movement. Our focus has been on whole body pointing tasks. The use of this task permits an understanding of how the nervous system controls the interaction of focal and postural modules.

2) Machine learning methods for identifying ensemble changes in the nervous system. These could be populations of neuronal activity, EMGs or kinematic patterns. With regards to classes, they could be different movement types or populations such as patients and controls.

3) Modifications of movement patterns with ageing


Previous research activities

1995- 2005:
Research assistant in the laboratory of Professeur T. Grisar, directeur of the Centre de la Neurobiologie Cellulaire et Moléculaire, Université de Liège, Belgique. My research activities during this period involved the following :

• In vitro sharp electrode recordings of the MCHR1 knockout mouse. The study focused on the alterations in the electrophysiological properties of neurons in the hippocampal CA1 area.
• Hodgkin-Huxley simulations in order to understand the connections between alterations in ionic channels and the development of synchrony between thalamic and cortical neurons. The synchronisation between these two systems is especially pertinent to sleep and epilepsy.
• The development of a neural network (Kohonen network) for the analysis of population encoding in the inferior temporal cortex of the monkey. The experimental data for the project was supplied by researchers from the Katholieke Universiteit Leuven (KUL).
• The development of a computer model of habituation and its deficits in the auditory cortex. The work was carried out in collaboration with clinicians treating people with migraine at the Neurology Department of the Medical School at the University of Liège.

Postdoctoral fellow. Department of Nuerology, University of Wisconsin, United States.
• Use of neural network simulation packet NEURON in order to study the effects of modifications in GABAA on network synchrony.

Research Assistant, University of Texas, Texas, U.S.A.
• Development of computational model for the study of thalamocortical synchronization during sleep.


Thomas E, French R, Alizee G and Coull J (2019) Having your cake and eating it: Faster responses with reduced muscular activation while learning a temporal interval. Neuroscience 410:68-75.

Casteran M, Hilt PM, Mourey F, Manckoundia P, French R and Thomas E (2018) Shifts in key time points and strategies for a multisegment motor task in healthy aging subjects. J Gerontol A Biol Sci Med Sci 73:1609-1617.

Embodiment and the origin of interval timing: kinematic and electromyographic data. Addyman C, Rocha S, Fautrelle L, French RM, Thomas E and Mareschal D (2017) Exp Brain Res 235:923-930.

Torlay L, Perrone-Bertolotti M, Thomas E and Baciu M (2017)
Machine learning-XG boost analysis of language networks to classify patients with epilepsy. Brain Informatics DOI 10.1007/S40708-017-0065-7.

Addyman C, French RM, Thomas E (2016)
Computational models of interval timing. Current opinion in Behavioral Sciences 8:140-146.

Casteran M, Putot A, Pfitzenmeyer F, Thomas E, Manckoundia P (2016)
Analysis of the impact of a cognitive task on the posture of elderly subjects with depression compared with healthy elderly subjects. Clin Neurophysiol 127:3406-3411.

Thomas E and French RM (2016)
Grandmother cells: much ado about nothing. Language, Cognition and Neuroscience. DOI: 10.1080/23273798.

Addyman C, French R and Thomas E (2015)
Computational models of interval timing. Current Opinions in Behavioral Sciences. (accepted)

French, R. M. and Thomas, E. (2015).
Interactive Effects of Explicit Emergent Structure: A Major Challenge for Cognitive Computational Modeling. Topics in Cognitive Science, 7(2), 206-216.

Fautrelle L, Mareschal D, French R and Thomas E (2015)
Motor activity improves temporal expectancy. PLoS One doi 10.1371/journal.pone.0119187.

Laroche D, Tolambiya A, Morisset C, Maillefert JF, French RM, Ornetti P, Thomas E (2014)
A classification study of kinematic gait trajectories in hip osteoarthritis. Computers in Medicine and Biology 55:42-48.

French RM, Addyman C, Mareschal D and Thomas E (2014)
GAMIT: A fading Gaussian activation model of interval-timing: Unifying prospective and retrospective time estimation. Timing and Time Perception Reviews 1:2.

Casteran Matthieu, Manckoundia Patrick, Pozzo Thierry, Thomas Elizabeth (2013). Alterations with Movement Duration in the Kinematics of a Whole Body Pointing Movement. PLoS ONE 8(1): e52477. doi:10.1371/journal.pone.0052477

Tolambiya A, Chiovetto E, Pozzo T and Thomas E (2012) Modulation of anticipatory postural activity for multiple conditions of whole body pointing tasks. Neuroscience 210:179-190.

Addyman, C., French, R. M., Mareschal, D., and Thomas, E. (2011). Learning to perceive time: A connectionist, memory-decay model of the development of interval timing in infants. In Proceedings of the Thirty-Third Annual Cognitive Science Society Conference, 354-359.

Tolambiya A, Thomas E, Chiovetto E, Berret B, Pozzo T (2011) An Ensemble Analysis of Electromyographic Activity during Whole Body Pointing with the Use of Support Vector Machines. PLoS One 6(7): e20732.

S. Nair, R. French, D. Laroche, E. Thomas (2010) The Application of machine learning algorithms to the analysis of electromyographic patterns from arthhritic patients. IEEE Transactions on Neuronal Systems and Rehabilitation Engineering 18: 174-184.

French, R. M. and Thomas, E. (2008) From Associations to Rules: Connectionist Models of Behavior and Cognition. Singapore: World Scientific.

Laroche D, Ornetti P, Thomas E, Ballay Y, Maillefert JF, Pozzo T (2007) Kinematic adaptation of locomotor pattern in rheumatoid arthritis patients with forefoot impairements. Exp Brain Res. 176(1):85-97.

Waroux O, Massote L, Alleva L, Graulich A, Thomas E, Liégois J-F, Scuvée-Moreau J and Seutin V (2005) SK channels control the firing pattern of midbrain dopaminergic neurons in vivo. European J Neuroscience 21: 2837-44

Thomas E , Adamantidis A, Foidart A, Tyhon A, Coumans B, Minet A, Tirelli E, Seutin V, Grisar T and Lakaye B (2005) Disrupting the melanin concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function; European J Neuroscience 21: 2837-44. (reviewed in Highlights of Nature Neuroscience Reviews 6:501) PDF file

Scuvée-Moreau J, Boland A, Graulich A, Van Overmeire L, D’hoedt D, Graulich-Lorge F, Thomas E, Abras A, Stocker M, Liégois J-F & Seutin V (2004) Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices. British J of Pharamacology 143: 753-764.

Thomas E. (2002) Modeling Individual Neurons and Small Neural Networks. Dans Nadel L. (ed) Encyclopaedia of Cognitive Science, Vol 3: 59-66. London, Nature Publishing Group.

Lakaye B., Thomas E., Minet A. & Grisar T. (2002) The Genetic Absence Epilepsy Rat from Strasbourg (GAERS), a rat model of absence epilepsy: Computer modeling and differential gene expression. Epilesia 43 Suppl 5: 123-9.

Thomas E., Sandor P., Ambrosini A. & Schoenen J. (2002) A neural network model of sensitization and intensity dependence in migraine. Cephalalgia 22:48-53.

French R. M. & Thomas E. (2001) The dynamical hypothesis in cognitive science: A review essay of Mind as Motion. Minds and Machines 11:101-111.

Thomas E., Van Hulle M. & Vogels R. (2000).Encoding of categories by non-category specific neurons in the inferior temporal cortex. Journal of Cognitive Neuroscience 13:190-200

Thomas, E.
& Grisar T. (2000) Increased synchrony with increase of a low threshold calcium conductance in a model thalamic network: a phase shift mechanism. Neural Computation 12: 1553-1573.

French R. M. & Thomas E. (2000) Why localist connectionist models are inadequate for categorization. The Behavior and Brain Sciences 23(4), 477.

Thomas E. (1999) Dynamics of thalamocortical spindle oscillations. Oscillations in Neural Systems, Erlbaum, New York p 133-148.

Thomas E., Van Hulle M. and Vogels R (1998) The study of the neuronal encoding of categorization with the use of a Kohonen network. Proceedings, 5th Neural Computation and Psychology Workshop. Connectionist Models in Cognitive Neuroscience. Birmingham, England, Springer Verlag, 1998.

French, R. M & Thomas, E. (1998) The Dynamical Hypothesis: One Battle Behind. The Behavior and Brain Sciences, 21: 615-665.

Thomas E. & Lytton W. (1997) Computer model of antiepileptic effects mediated by alterations in GABAA mediated inhibition. NeuroReport 9(4): 691-696.

Thomas E & Grisar T (1997) Transition to Subthreshold activity with the use of phase shifting in a model thalamic network. Applied Nonlinear Dynamics and Stochastic Systems near the Millenium. AIP Conference Proceedings 411: 303-309.

Lytton W. & Thomas E. (1997) Modeling thalamocortical oscillations. In Cerebral Cortex. Volume 13. Models of Cortical Circuitry. Philip S. Ulinski and Edward G. Jones (Editors), Plenum Press, New York.

Grisar T., Lakaye B. & Thomas E. (1996) Molecular basis of neuronal biorhythms and paroxysms. Archives of Physiology and Biochemistry 104: 770-774.

Thomas E. & Wyatt R. (1995) A computational model of thalamocortical spindle oscillations. Mathematics and Computers in Simulation 40: 35-69. Elsevier Press, Amsterdam.

Thomas E., Patton P., & Wyatt R. (1991) A computational model of the vertical anatomical organization of primary visual cortex. Biological Cybernetics 65: 189-202.

Patton P., Thomas E., & Wyatt R. (1992) A computational model of vertical signal propagation in the primary visual cortex. Biological Cybernetics 68: 43-52.




ANR-10-ORAR-006-03 Grounding Early Time Perception in Motor Activity 92 000

Electrophysiological analysis of thalamic brain slices from the GAERS rat model of absence epilepsy. Fonds Spéciaux pour la Recherche, Crédits Classiques, Université de Liège €37 500

Electrophysiological and pharmacological characterisation of rat mesencepahlic dopaminergic neurons. Fonds National de Recherche Scientifique (FNRS) Belgique €10 000

Rehabilitation through the use of motor cognition and virtual reality. Plan d’actions régional pour l’innovation. Postdoctoral grant. Conséil Régional de Bourgogne, France. € 24 000


Principal Investigator

The use of neural networks for the analysis and automatic classification of locomotor deficits. Conseil Régional de Bourgogne, France. € 45 000

The use of artificial neural networks and kernel methods for the analysis of kinematic and electromyographic data recorded during gait. Foreign postdoctoral grant. Conseil Régional de Bourgogne, France. € 24 000


Download PDF Lessons

L1 :

- Introduction à la Neuroanatomie et la Neurophysiologie
- Le système nerveux: contrôle du mouvement
- Les reflexes et programs spinaux
- Contrôle central du mouvement
- Les voies motrices descendantes
- Système sensoriel somatique
- Testez votre connaisance
- Corrigé Testez votre connaisance


L3 APA :

Trauma of the Spinal Cord

- Part 1
- Part 2
- Part 3
- Test 2013


M1 APA :

- Déficience, plasticité et réapprentissage de la fonction perceptivo-motrice
- La régénération axonale
Des Anomalies de l’Atteinte, Saisie et Manipulation des Objets
- Quelques stratégies d'intervention


MVibot :

- Human Vision: Electrophysiology and Psychophysics
- Onto the Brain !
- Depth perception
- Artificial Neural Networks: Self Organizing Networks
- The study of the neuronal encoding of visual categorization with the use of a Kohonen network
- The Retina
- Human Vision: Electrophysiology and Psychophysics


M2 :

- Diseases of the neuromuscular system
- L’emploi des outils computationnels en vue de la compréhension du système neuromusculaire
- A Classification Study of Kinematic Gait Variables in Hip Osteoarthritis

Read more: Elizabeth Thomas

Christian Darlot

homme email christian.darlot{[at]} adresse Laboratoire INSERM U1093
Université de Bourgogne
Faculté des Sciences du Sport (UFR Staps)
BP 27877
21078 Dijon
telephone +33 3 80 39 67 12
fax +33 3 80 39 67 49
bureau Room n°123

Read more: Christian Darlot

Thierry Pozzo

Thierry Pozzo email thierry.pozzo{[at]} adresse Laboratoire INSERM U1093
Université de Bourgogne
Faculté des Sciences du Sport (UFR Staps)
BP 27877
21078 Dijon
telephone +33 3 80 39 67 56
fax +33 3 80 39 34 47
bureau Room n°122


Neurosciences, Control moteur, Couplage Perception-Action, Cognition Motrice, Modèles computationnels


Curriculum Vitae

Après un DEA à Marseille en 1985, j’ai préparé un doctorat sous la direction de A. Berthoz. Après une thèse de neurophysiologie (Paris VI) en 1990 et plusieurs séjours à l’étranger je suis devenu en 1992 MCU STAPS à Dijon. PU en 1998, j’ai pris en 2000 la direction d’une EA et je dirige cette unité INSERM depuis 2002. En délégation INSERM de 2003-2005, j’ai été professeur invité à la Faculté de Médecine de Pavie. Depuis 2007 je participe à l’implantation d’une plateforme européenne de robotique humanoïde à l’Institut Italien de Technologie de Gènes.

Thèmes de recherche

Mon projet de recherche consiste à étudier les principes d’organisation de la motricité humaine et à identifier les mécanismes physiologiques sous-jacents. Les 3 axes de recherche que je propose de développer tiennent compte de récentes avancées en neurosciences qui suggèrent un étroit couplage entre Action et Perception. Perception et planification des actions seront étudiés (psychophysiques, TMS, IRMf) afin de mieux comprendre les mécanismes responsables de la production des actions. Le projet prévoit de valoriser médicalement nos résultats et de développer des outils thérapeutiques innovants pour rééduquer les âgés hypo actifs ou les patients souffrant de lésions centrales. La recherche est conduite au sein de l’U887 et en collaboration avec plusieurs équipes internationales dont C Vargas à Rio, L Fadiga à Genova, N Stucchi à Milano.



Physiologie de la vérité / Thierry Pozzo

La beauté universelle du mouvement humain / Thierry Pozzo

Intelligence Artificielle et Avatar d’Intelligence : L’intelligence Artificielle (IA) serait elle atteinte du syndrome de Pinocchio?

EJ Marey: L’invention de la Trace graphique et le Démontage du vivant

Leçons scientifiques et médicales des vols spatiaux


Art & Olfaction - Une part profonde de l’être



Raconte-moi un visionnaire, Etienne-Jules Marey



Tia B, Paizis C, Mourey F, Pozzo T (2012).
Do equilibrium constraints modulate postural reaction when viewing imbalance?
Brain & Cognition (sous presse).

Sciutti A, Demougeot L, Berret B, Sandini G, Papaxanthis C, Pozzo T (2012)
Visual gravity influences arm movement planning.
J of Neurophysiol (sous presse).

Tolambiya A, Berret B, E Chiovetto, Pozzo T, Thomas E (2012)
Multidimensional tuning of anticipatory postural activity during whole body pointing.
Neuroscience, (sous presse).

Sciutti A, Bisio A, Nori F, Metta G, Fadiga L, Pozzo T, Sandini G (2012).
Measuring human-robot interaction through motor resonance.
International Journal of Social Robotics, in press.

Chiovetto E, Patanè L, Pozzo T (2012)
Variant and invariant features characterizing natural and reverse whole-body pointing movements.
Exp Brain Res (sous presse).

Casellato C, Tagliabue M, Pedrocchi A, Papaxanthis C, Ferrigno G, Pozzo T (2012)
Whole body reaching in weightlessness: New postural control to simplify the motor strategy.
Exp Brain Res, 216(2):203-15.


Berret B, Chiovetto E, Nori F, Pozzo T (2011)get pdf
Evidence for Composite Cost Functions in Arm Movement Planning: An Inverse Optimal Control Approach.
PLoS Comput Biol, 7(10): e1002183.

Berret B, Chiovetto E, Nori F, Pozzo T (2011)get pdf
The manifold reaching paradigm: how do we handle target redundancy?
J of Neurophysiol, 106(4):2086-102.

Tolambiya A, Thomas E, Berret B, Pozzo T (2011)
An Ensemble Analysis of Electromyographic Activity During Whole Body Pointing with the use of Support Vector Machines.
Plos One, 6(7):e20732.

Tia B, Saimpont A, Paizis C, Mourey F, Fadiga L, Pozzo T (2011)
Does observation of postural imbalance induce a postural reaction?
Plos One, 6(3):e17799.

Perrot O, Laroche D, Pozzo T, Marie C (2011)
Kinematics of obstacle clearance in the rat.
Behavioural Brain Research, 224(2):241-9.

Gaveau J, Paizis C, Berret B, Pozzo T, Papaxanthis C (2011)
Sensorimotor adaptation of point-to-point arm movements after space-flight: the role of the internal representation of gravity force in trajectory planning.
J Neurophysiol, 106(2):620-9.

Avanzino L, Bassolino M, Pozzo T, Bove M (2011)get pdf
Use-dependent hemispheric balance.
J of Neurosciences 31:3423-3428


Tia B, Mourey F, Ballay Y, Sirandré C, Pozzo T, Paizis C (2010).
Improvement of motor performance by observational training in elderly people.
Neuroscience Lett 480(2):138-42

Saimpont A, Mourey F, Manckoundia P, Pfitzenmeyer P, Pozzo T (2010)
Aging affects the mental simulation/planning of the "rising from the floor" sequence.
Arch Gerontol Geriat 51 : 41-45

Fautrelle L, Berret B, Chiovetto E, Pozzo T,
Bonnetblanc F (2010) Equilibrium constraints do not affect the timing of muscular synergies during the initiation of a whole body reaching movement.
Exp Brain Res 203:147-58

Chiovetto E, Berret B, Pozzo T (2010)
Tri-dimensional and triphasic muscle organization of whole-body pointing movements.
Neuroscience 170(4):1223-38

Bisio A, Stucchi N, Jacono M, Fadiga L, Pozzo T (2010)get pdf
Automatic versus voluntary motor imitation: effect of visual context and stimulus velocity.
PLoS One 5(10): e13506


Vieira S, Quercia P, Michel C, Pozzo T, Bonnetblanc F (2009)
Cognitive demands impair postural control in developmental dyslexia: a negative effect that can be compensated.
Neurosci Lett 22:125-9

Saimpont A, Pozzo T, Papaxanthis C (2009)
Aging affects the mental rotation of left and right hands.
PLoS One 26:4(8)

Perrot O, Laroche D, Pozzo T, Marie C (2009)
Quantitative Assessment of Stereotyped and Challenged Locomotion after Lesion of the Striatum: A 3D Kinematic Study in Rats.
PLoS One 4:10(11)

Fazio P, Cantagallo A, Craighero L, D'Ausilio A, Roy AC, Pozzo T, Calzolari F, Granieri E, Fadiga L (2009)
Encoding of human action in Broca's area.
Brain 132:1980-8

Berret B, Bonnetblanc F, Papaxanthis C, Pozzo T (2009)get pdf
Modular control of pointing beyond arm’s length.
J of Neuroscience 29:191-205


Eskiizmirliler S, Papaxanthis C, Pozzo T, Darlot C (2008)
A model of the cerebellar sensory - motor control applied to fast human forearm movements.
J Integr Neurosci 7:481-500

Paizis C, Berret B, Papaxanthis C, Pozzo T (2008)
Reaching beyond arm length in normal aging: adaptation of hand trajectory and dynamic equilibrium.
Behav Neuroscience 122:1361-70

Berret B, Darlot C, Jean F, Pozzo T, Papaxanthis C, Gauthier JP (2008)
The inactivation principle: mathematical solutions minimizing the absolute work and biological implications for the planning of arm movements.
PLoS Comput Biol, 29:191-205

Skoura X, Personnier P, Vinter A, Pozzo T, Papaxanthis C (2008)
Decline in motor prediction in elderly subjects: right versus left arm differences in mentally simulated motor actions.
Cortex 44:1271-127


Barbieri G, Gissot AS, Fouque F, Casillas JM, Pozzo T, Perennou D (2007)
Does proprioception contribute to the sense of verticality ?
Exp Brain Res 185:545-552.

Tagliabue M, Pedrocchi A, Pozzo T, Ferrigno G (2007)
A mathematical tool to generate complex whole body motor tasks and test hypotheses on underlying motor planning.
Medical & Biological Engineering & Computing 46:11-22

Saunier G, Papaxanthis C, Vargas C, Pozzo T (2007)
Inference of complex human motion requires internal models of action: behavioral evidence.
Exp Brain Res 185:399-409

Michel C, Vernet P, Courtine G, Ballay Y, Pozzo T (2007)
Is locomotor reaching more sensitive than manual pointing to representational bias induced by visuo-manual adaptation to prisms?
Exp Brain Res 185:259-68

Laroche D, Ornetti P, Thomas E, Ballay Y, Maillefert JF,Pozzo T (2007)
Kinematic adaptation of locomotor pattern in rheumatoid arthritis patients with forefoot impairment.
Exp Brain Res 176:85-97

Casellato C, Tagliabue M, Pedrocchi A, Ferrigno G, Pozzo T (2007)
How does microgravity affect the muscular and kinematic synergies in a complex movement?
J Gravit Physiol, 14(1):93-4


Pozzo T, Vernet P, Creuzot-Garcher C, Robichon F, Bron A, Quercia P (2006)
Static Postural control in children with developmental dyslexia.
Neurosc Letter 403:211-215.

Schmid M, Schieppati M, Pozzo T (2006)
Effect of the fatigue on the precision of a whole body pointing task.
Neuroscience 139:909-920

Pozzo T, Papaxanthis C, Petit JL, Schweighofer N, Stucchi N (2006)
Kinematic features of movement tunes perception and action coupling.
Behav Brain Res 169:75-82

Gentili R, Papaxanthis C, Pozzo T (2006)
Improvement and generalization of arm motor performance through motor imagery practice.
Neuroscience 137: 761-772


Skoura X, Papaxanthis C, Vinter A, Pozzo T (2005)
Mentally represented motor actions in normal aging. I. Age effects on the temporal features of overt and covert execution of actions.
Behav Brain Res 165: 229-239.

Quercia P, Seigneuric A, Chariot S, Vernet P, Pozzo T, Bron A, Creuzot-Garcher C, Robichon F (2005)
Ocular proprioception and developmental dyslexia. Sixty clinical observations.
J Fr Ophtalmol 28: 713-723

Patron J, Stapley P, Pozzo T (2005)
Human whole-body reaching in normal gravity and microgravity reveals a strong temporal coordination between postural and focal task components.
Exp Brain Res 165: 84-96

Papaxanthis C, Pozzo T, McIntyre J (2005)
Kinematic and dynamic processes for the control of pointing movements in humans revealed by short-term exposure to microgravity.
Neuroscience 135: 371-383

Laroche D, Pozzo T, Ornetti P, Tavernier C, Maillefert JF (2005)
Effects of loss of metatarsophalangeal joint mobility on gait in rheumatoid arthritis patients.
Rheumatology (Oxford) 45:435-440


Tagliabue M, Pedrocchi A, Gower V, Ferrigno G, Pozzo T (2004)
Whole body pointing movements in transient microgravity: preliminary results.
J Gravit Physiol 11: P39-40.

Patron J, Stapley PJ,Pozzo T (2004)
Temporal relationship between postural and focal components of a whole-body reaching movement: a study case of short-term adaptation in microgravity condition.
J Gravit Physiol 11: 23-24

Courtine G, Pozzo T (2004)
Recovery of the locomotor function after prolonged microgravity exposure. I. Head-trunk movement and locomotor equilibrium during various tasks.
Exp Brain Res 158: 86-99

Courtine G, Papaxanthis C, Gentili R, Pozzo T (2004)
Gait-dependent motor memory facilitation in covert movement execution.
Brain Res Cogn Brain Res 22: 67-75


Papaxanthis C, Pozzo T, Schieppati M (2003)
Trajectories of arm pointing movements on the sagittal plane vary with both direction and speed.
Exp Brain Res 148: 498-503.

Papaxanthis C, Pozzo T, Kasprinski R, Berthoz A (2003)
Comparison of actual and imagined execution of whole-body movements after a long exposure to microgravity.
Neurosci Lett 339: 41-44

Papaxanthis C, Dubost V, Pozzo T (2003)
Similar planning strategies for whole-body and arm movements performed in the sagittal plane.
Neuroscience 117: 779-783

Courtine G, Papaxanthis C, Laroche D, Pozzo T (2003)
Gait-dependent integration of neck muscle afferent input.
Neuroreport 14: 2365-2368


Pozzo T, Stapley PJ, Papaxanthis C (2002)
Coordination between equilibrium and hand trajectories during whole body pointing movements.
Exp Brain Res 144: 343-350.

Patron J, Stapley P, Pozzo T (2002)
Evidence of short-term adaptation to microgravity of neuromuscular synergy during a whole body movement.
J Gravit Physiol 9: 167-168

Papaxanthis C, Schieppati M, Gentili R, Pozzo T (2002)
Imagined and actual arm movements have similar durations when performed under different conditions of direction and mass.
Exp Brain Res 143: 447-452

Papaxanthis C, Pozzo T, Skoura X, Schieppati M (2002)
Does order and timing in performance of imagined and actual movements affect the motor imagery process? The duration of walking and writing task.
Behav Brain Res 134: 209-215

34) Courtine G, Pozzo T (2002)
Head position during various locomotor executions after prolonged microgravity exposure.
J Gravit Physiol 9: 163-164

Courtine G, Papaxanthis C, Pozzo T (2002)
Prolonged exposure to microgravity modifies limb endpoint kinematics during the swing phase of human walking.
Neurosci Lett 332: 70-74


Pozzo T, Ouamer M, Gentil C (2001)get pdf
Simulating mechanical consequences of voluntary movement upon whole-body equilibrium: the arm-raising paradigm revisited.
Biol Cybern 85: 39-49

Courtine G, Pozzo T, Schieppati M (2001)
Continuous leg muscle vibration is not detrimental to human walk.
Brain Res Bull 55 : 107-115

Courtine G, Pozzo T, Schieppati M (2001)
Vibration after effect during human walking.
J Soc Biol 195: 443-446

Bove M, Diverio M, Pozzo T, Schieppati M (2001)
Neck muscle vibration disrupts steering of locomotion.
J Appl Physiol 91: 581-588


Stapley P, Pozzo T, Grishin A, Papaxanthis C (2000)
Investigating centre of mass stabilisation as the goal of posture and movement coordination during human whole body reaching.
Biol Cybern 82: 161-172.

Mourey F, Grishin A, d'Athis P, Pozzo T, Stapley P (2000)
Standing up from a chair as a dynamic equilibrium task: a comparison between young and elderly subjects.
J Gerontol A Biol Sci Med Sci 55: B425-431


Stapley PJ, Pozzo T, Cheron G, Grishin A (1999)
Does the coordination between posture and movement during human whole-body reaching ensure center of mass stabilization?
Exp Brain Res 129: 134-146.

Kerlirzin Y, Pozzo T, Dietrich G, Vieilledent S (1999)
Effects of kinematics constraints on hand trajectory during whole-body lifting tasks.
Neurosci Lett 277: 41-44


Stapley P, Pozzo T, Grishin A (1998)
The role of anticipatory postural adjustments during whole body forward reaching movements.
Neuroreport 9: 395-401.

Stapley P, Pozzo T (1998)get pdf
Does the centre of mass remains stable during complex human postural equilibrium tasks in weightlessness?
Acta Astronaut 43: 163-179

Pozzo T, Papaxanthis C, Stapley P, Berthoz A (1998b)get pdf
The sensorimotor and cognitive integration of gravity.
Brain Res Brain Res Rev 28: 92-101)

Pozzo T, McIntyre J, Cheron G, Papaxanthis C (1998a) Hand trajectory formation during whole body reaching movements in man.
Neurosci Lett 240: 159-162

Papaxanthis C, Pozzo T, Vinter A, Grishin A (1998)
The representation of gravitational force during drawing movements of the arm.
Exp Brain Res 120: 233-242

Papaxanthis C, Pozzo T, Van Hoecke J, Vinter A, Skoura X (1998)Drawing movements and gravitational force: central or peripheral regulation?
C R Seances Soc Biol 192: 187-193

Papaxanthis C, Pozzo T, Stapley P (1998)
Effects of movement direction upon kinematic characteristics of vertical arm pointing movements in man.
Neurosci Lett 253: 103-106

Papaxanthis C, Pozzo T, Popov KE, McIntyre J (1998)
Hand trajectories of vertical arm movements in one-G and zero-G environments. Evidence for a central representation of gravitational force.
Exp Brain Res 120: 496-502

Papaxanthis C, Pozzo T, McIntyre J (1998)
Arm end-point trajectories under normal and micro-gravity environments.
Acta Astronaut 43: 153-161

Mourey F, Pozzo T, Rouhier I, Didier JP (1998)
A Kinematic comparison between elderly and young subjects during standing up from and sitting down to a chair.
Age and Aging 27: 137-146

Marzani F, Legrand L, Pozzo T (1998)
Vers l’analyse du mouvement tridimensionnel du corps humain.
Science et Sports, 12 : 3-7


Cheron G, Bengoetxea A, Pozzo T, Bourgeois M, Draye JP (1997)
Evidence of a preprogrammed deactivation of the hamstring muscles for triggering rapid changes of posture in humans.
Electroencephalogr Clin Neurophysiol 105: 58-71.


Papaxanthis C, Pozzo T (1996)
Search of gravity force in the planning of arm pointing movements.
C R Seances Soc Biol 190: 613-619.

Mourey F, Pozzo T (1996)
Effects of aging on standing up and sitting down. Kinematic analysis.
C R Seances Soc Biol 190: 603-611


Pozzo T, Levik Y, Berthoz A (1995b)
Head and trunk movements in the frontal plane during complex dynamic equilibrium tasks in humans.
Exp Brain Res 106: 327-338.

Pozzo T, Berthoz A, Popov C (1995a)get pdf
Effect of weightlessness on posture and movement control during a whole body reaching task.
Acta Astronaut 36: 727-732/p>


Vitte E, Borel L, Pozzo T, Perrin P, Freyss G (1992)
Vestibular studies: current status, prospects.
Ann Radiol (Paris) 35: 26-35.


Pozzo T, Berthoz A, Vitte E, Lefort L (1991b)
Head stabilization during locomotion. Perturbations induced by vestibular disorders.
Acta Otolaryngol Suppl 481: 322-327.

Pozzo T, Berthoz A, Lefort L, Vitte E (1991a)
Head stabilization during various locomotor tasks in humans. II. Patients with bilateral peripheral vestibular deficits.
Exp Brain Res 85: 208-217


Pozzo T, Berthoz A, Lefort L (1990)
Head stabilization during various locomotor tasks in humans. I. Normal subjects.
Exp Brain Res 82: 97-106.


Pozzo T, Berthoz A, Lefort L (1989)
Head kinematic during various motor tasks in humans.
Prog Brain Res 80: 373-383.


Pozzo T, Clement G, Berthoz A (1988)
Motor control of a handstand.
Agressologie 29: 649-651.

Clement G, Pozzo T, Berthoz A (1988)
Contribution of eye positioning to control of the upside-down standing posture.
Exp Brain Res 73: 569-576

Pozzo T, Clément G (1988
Application de la stabilométrie à l'étude des mécanismes moteurs d'une figure acrobatique : l'appui tendu renversé.
Science & Sports 3 ; 173-180

Read more: Thierry Pozzo

François Bonnetblanc

François-Bonnetblanc email francois.bonnetblanc{[at]} adresse Laboratoire INSERM U1093
Université de Bourgogne
Faculté des Sciences du Sport (UFR Staps)
BP 27877
21078 Dijon
telephone +33 3 80 39 67 62
fax +33 3 80 39 34 47
bureau Room n°201

Read more: François Bonnetblanc

Lionel Crognier

Director of UFR STAPS
lionel-crognier email lionel.crognier{[at]} adresse Laboratoire INSERM U1093
Université de Bourgogne
Faculté des Sciences du Sport (UFR Staps)
BP 27877
21078 Dijon
telephone +33 3 80 39 67 11
fax +33 3 80 39 67 49
bureau Room R07

Read more: Lionel Crognier

Patrick Manckoundia

Patrick-Manckoundia email patrick.manckoundia{[at]}chu-dijon adresse  
telephone +33 3 80 29 39 70
bureau Room n°


Présentation :

Je suis médecin spécialiste en Médecine Interne depuis 2002 et en Gériatrie depuis 2005.
Je me suis très tôt intéressé à l'enseignement et à la recherche sous l'impulsion du Professeur Pierre Pfitzenmeyer et du Docteur France Mourey.
Mon axe de recherche est "troubles de l'équilibre et de la marche dans le vieillissement normal et pathologique".
J'ai notamment réalisé des travaux sur la double tâche et le passage assis-debout.
J'ai ainsi obtenu un DEA puis un doctorat de neurosciences en 2006 et une HDR en 2007 avant d'être nommé Professeur des Universités-Praticien Hospitalier en 2009.


Domaines d’expertise :

- Evaluation de l’équilibre et de la marche chez le sujet âgé normal
- Evaluation de l’équilibre et de la marche chez le sujet âgé malade, notamment atteint de la maladie d'Alzheimer
- Le syndrome de désadaptation psychomotrice
- Fragilité des fonctions motrices : approche clinique et fondamentale


Publications :

Manckoundia P, Pfitzenmeyer P, d’Athis Ph, Dubost V, Mourey F.
Impact of cognitive task on the posture of elderly subjects with Alzheimer’s disease compared to healthy elderly subjects.
Mov disord 2006;21:236-41.

Manckoundia P, Mourey F, Pfitzenmeyer P, Papaxanthis C.
Comparison of motor strategies in sit-to-stand and back-to-sit motions between healthy and Alzheimer’s disease elderly subjects.
Neuroscience 2006;137:387-92.

Manckoundia P, Mourey F, Pfitzenmeyer P, Van Hoecke J, Pérennou D.
Is backward disequilibrium in the elderly caused by an abnormal perception of verticality? A pilot study.
Clin Neurophysiol 2007;118:786-93.

Manckoundia P, Guize L, Thomas F, Buatois S, Benetos A.
Impact of clinical, psychological and social factors on the evolution of Tinetti test in community-living elderly subjects: a prospective study with a 2-year follow-up.
Med Sci Monit 2008;14:CR316-22.

Matheron E, Dubost V, Mourey F, Pfitzenmeyer P, Manckoundia P.
Analysis of postural control in elderly subjects suffering from psychomotor disadaptation syndrome.
Arch Gerontol Geriatr 2010;51:e19-23.

Read more: Patrick Manckoundia

France Mourey

France Mourey email france.mourey{[at]} adresse Laboratoire INSERM U1093
Université de Bourgogne
Institut Marey, Maison de la Métalurgie
64 rue de Sully
21000 Dijon
telephone +33 3 80 39 67 65
fax +33 3 80 39 34 47
bureau Room n°202


I was born in 1955. I obtained my physiotherapy diploma in 1976. From 1881 to 2009 I worked in the Geriatric Hospital of Dijon ( Pr Michel Gaudet and Pr Pierre Pfitzenmeyer) as chief of a geriatric rehabilitation team. I have carried out clinical research concerning motor frailty, problems in equilibrium, falls and post-fall syndrome. My PhD at the University of Burgundy was on the effects of ageing on posture and movement with an emphasis on standing up and sitting down.


Areas of Expertise

• Assessment of balance function and gait in elderly
• Frailty of motor function and clinical approach
• Ethical aspects
• assessment and training of motor function in Alzheimer disease


Articles :

Mourey F, Manckoundia P, Martin-Arveux I, Tavernier-Vidal B, Pfitzenmeyer P .
Psychomotor disadaptation. A new clinical entity in geriatric patients. Geriatrics 2004 ;59 :20-24.

Manckoundia Patrick, Mourey France, Pfitzenmeyer Pierre, Van Hoecke Jacques, Pérennou. Dominic.
Is Backward disequilibrium in the elderly caused by an abnormal perception of verticality? Clinical neurophysiological 118; 2007:786-793

Tia B, Mourey F, Ballay Y, Sirandré C, Pozzo T, Paizis Ch.
Improvement of motor performance by observational training in elderly people. Neurosci Lett. 2010 Aug 16;480(2):138-42.

Kubicki A, Petrement G, Bonnetblanc F, Ballay Y, Mourey F.
Practice-related improvements in postural control during rapid arm movement in older adults. 2011 J Gerontol. J Gerontol A Biol Sci Med Sci. 2012 Feb;67(2):196-203.

Bisio A, Casteran M, Ballay Y, Manckoundia P, Mourey F, Pozzo. T.
Motor resonance mechanisms are preserved in Alzheimer’s disease patients. Neuroscience 2012,222 :58–68

Manckoundia P Taroux M, Kubicki A , Mourey F.
</>Impact of ambulatory physiotherapy on motor abilities of elderly subjects with Alzheimer's disease. Geriatr Gerontol Int. 2014 Jan;14(1):167-75

Kubicki A, Petrement G, Bonnetblanc F, Mourey
F Motor-prediction improvements after virtual rehabilitation in geriatrics: frail patients reveal different learning curves for movement and postural control in Neurophysiologie Clinique/Clinical Neurophysiology .2014;44, 109-118.

Read more: France Mourey

Charalambos Papaxanthis

Director of the U1093
Charalambos-Papaxanthis email charalambos.papaxanthis{[at]} adresse Laboratoire INSERM U1093
Université de Bourgogne
Faculté des Sciences du Sport (UFR Staps)
BP 27877
21078 Dijon
telephone +33 3 80 39 67 48
fax +33 3 80 39 67 49
bureau Room n°124



Neurosciences, contrôle moteur, apprentissage moteur, plasticité sensorimotrice cognition motrice


1991   DEA: "Evaluation et amélioration de la performance motrice". Université de Bourgogne.
1992   Diplôme Universitaire de la psychologie du sport, Université de Reims. Université de Bourgogne.
1998   Thèse: "Représentation centrale de la force gravitaire lors des mouvements du bras". Université de Bourgogne.
2004   Habilitation à Diriger des Recherches: "Traitement sensorimoteur et cognitif du champ gravito-inertiel".
2004   DESS: "Entraînement et management sportifs", Université de Bourgogne.

Research Topics

Mes travaux de recherche s’inscrivent dans le domaine des neurosciences comportementales, computationnelles et cognitives chez l’homme. Le 1er axe de recherche consiste à comprendre l’intégration de la force gravitaire dans le contrôle du mouvement lors des expositions à des environnements variés (gravité normale, microgravité, hyper-gravité). Le 2ème vise les mécanismes neurophysiologiques sous-jacents aux opérations cérébrales du contrôle et de la simulation mentale du mouvement. Enfin, le 3ème axe explore la possibilité d’appendre un mouvement par simulation mentale ou par observation. Les principaux outils/méthodes de mon activité scientifique sont : l’analyse 3D du mouvement (cinématique et dynamique), l’activité électromyographique (EMG), la stimulation magnétique transcranienne (TMS), et les modèles computationnels du contrôle optimal.


Contrôle moteur, neurosciences cognitives, préparation mentale de l’athlète, Activités Physiques Adaptés et Santé, Anatomie du membre supérieur.

Read more: Charalambos Papaxanthis

Philippe Garnier

Philippe Garnier email philippe.garnier{[at]} adresse Laboratoire INSERM U1093
Université de Bourgogne
UFR Sciences de Santé
7 Bd jeanne d’Arc
21079 Dijon CEDEX
telephone +33 3 80 39 34 94
fax +33 3 80 39 32 27
bureau Room n°375A



Neurosciences Activité physique, AVC, activateur tissulaire du plasminogène (tPA) , Neuroplasticité, BDNF.


1998   D.E.A. de Biochimie, Biologie Cellulaire et Moléculaire. Université de Bourgogne Dijon, Besançon. “ Expression des ARNm et protéines HSP72 en réponse à l'ischémie cérébrale et à l'hypoxie chez la Gerbille. Incidence de l'apport sanguin en glucose ”
2001   Thèse de doctorat de l’Université de Bourgogne (mention biochimie et biologie moléculaire) “ Mort neuronale, expression protéique et réponse gliale chez la Gerbille soumise à une hypoxie et à une ischémie cérébrale transitoires ”
2001   Formation à l’expérimentation animale et méthodes alternatives, niveau 1
2002-2004   Stage post-doctoral dans le service de neurologie dirigé par le Pr. R. Swanson, Université de Californie à San Francisco
2008   Habilitation à Diriger des Recherches de l’Université de Bourgogne, "PARP-1 et ischémie cérébrale"

Research Topics

Mes travaux de recherche visent à comprendre les mécanismes de la neuroplasticité et plus précisément le lien entre la pratique d’une activité physique (AP) et l’amélioration de la santé cérébrale avec un focus sur le BDNF d’origine cérébrovasculaire. En effet, nous avons récemment mis en évidence que l’endothélium des microvaisseaux cérébraux était une source majeure du BDNF cérébral et que ce type cellulaire, à l’instar du neurone, répondait à l’AP par une augmentation de la production de BDNF. Ces découvertes sont à relier aux travaux montrant le lien entre santé vasculaire et santé cérébrale et suggèrent que le BDNF d’origine cérébrovasculaire pourrait avoir un rôle essentiel dans les effets bénéfiques de la pratique de l’AP via des effets neuroplastiques et/ou potentiellement vasodilatateurs. Plus précisément, par une approche utilisant des techniques de biochimie et de biologie moléculaire, je cherche à comprendre dans quelle mesure la production endothéliale de BDNF met en jeu l'activateur tissulaire du plasminogène (tPA), une protéase également produite par l'endothélium en réponse à l'AP et potentiellement capable d’augmenter la synthèse de BDNF via l’activation des récepteurs NMDA (N-methyl-D aspartate).


Biochimie structurale et métabolique, Ingénierie du génôme.


Depuis 2010

  • Alano CC, Garnier P, Ying W, Higashi Y, Kauppinen TM, Swanson RA (2010). NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death. J Neurosci. 30(8) : 2967-78.
  • Desrumaux C, Deckert V, Lemaire-Ewing S, Mossiat C, Athias A, Vandroux D, Dumont L, Monier S, Pais de Barros JP, Klein A, De Maistre E, Blache D, Beley A, Marie C, Garnier P, Lagrost L (2010). Plasma phospholipid transfer protein deficiency in mice is associated with a reduced thrombotic response to acute intravascular oxidative stress. Arterioscler Thromb Vasc Biol. 30(12):2452-7.
  • Béjot Y, Prigent-Tessier A, Cachia C, Giroud M, Mossiat C, Bertrand N, Garnier P, Marie C (2011). Time-dependent contribution of non-neuronal cells to BDNF production after ischemic stroke in rats. Neurochem Int. 58(1):102-11.
  • Heydel JM, Garnier P, Faure P, Artur Y (2012). Ciprofibrate regulation of rat hepatic bilirubin glucuronidation and UDP-glucuronosyltransferases expression. Eur J Drug Metab Pharmacokinet.
  • Quirié A, Hervieu M, Garnier P, Demougeot C, Mossiat C, Bertrand N, Martin A, Marie C, Prigent-Tessier A (2012). Comparative effect of treadmill exercise on mature BDNF production in control versus stroke rats. PLoS One. 7(9):e44218.
  • Quirié A, Demougeot C, Bertrand N, Mossiat C, Garnier P, Marie C, Prigent-Tessier A (2013). Effect of stroke on arginase expression and localization in the rat brain. Eur J Neurosci. 37(7):1193-202. doi: 10.1111/ejn.12111.
  • Madinier A, Bertrand N, Rodier M, Quirié A, Mossiat C, Prigent-Tessier A, Marie C, Garnier P (2013). Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF? Neuroscience. 231:169-81. doi: 10.1016/j.neuroscience.
  • Rodier M, Prigent-Tessier A, Béjot Y, Jacquin A, Mossiat C, Marie C, Garnier P (2014). Exogenous t-PA administration increases hippocampal mature BDNF levels. plasmin- or NMDA-dependent mechanism? PLoS One. 9(3):e92416. doi: 10.1371/journal.pone.0092416.
  • Rodier M, Quirié A, Prigent-Tessier A, Béjot Y, Jacquin A, Mossiat C, Marie C, Garnier P (2015). Relevance of Post-Stroke Circulating BDNF Levels as a Prognostic Biomarker of Stroke Outcome. Impact of rt-PA Treatment. PLoS One. 10(10):e0140668. doi: 10.1371/journal.pone.0140668. (IF=3.53)
  • Banoujaafar H, Monnier A, Pernet N, Quirié A, Garnier P, Prigent-Tessier A, Marie C (2016). Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide. Eur J Neurosci. 44(5):2226-35. doi: 10.1111/ejn.13301.
  • Monnier A, Prigent-Tessier A, Quirié A, Bertrand N, Savary S, Gondcaille C, Garnier P, Demougeot C, Marie C (2016). Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain. Acta Physiol doi: 10.1111/apha.12743.
  • Monnier A, Garnier P, Quirié A, Pernet N, Demougeot C, Marie C, Prigent-Tessier A (2016). Effect of short-term exercise training on brain-derived neurotrophic factor signaling in spontaneously hypertensive rats. J Hypertension : DOI: 10.1097/HJH.0000000000001164.



Responsable de la Licence Professionnelle Bioindustrie et Biotechnologie spécialité Culture de tissus et cellules et biologie moléculaire (CTCBM) depuis 2009.

Read more: Philippe Garnier

  • Anne Tessier

    Anne Tessier email anne.tessier{[at]} adresse Laboratoire INSERM U1093
    Université de Bourgogne
    7 Bd jeanne d’Arc
    UFR de pharmacie
    21079 Dijon CEDEX
    telephone +33 3 80 39 34 92
    fax +33 3 80 39 32 27
    bureau Room n°371



    Neurosciences, exercice physique, BDNF, plasticité cérébrale, ischémie cérébrale.


    1990 Concours d'Internat en Pharmacie, filière Pharmacie Spécialisée.
    1993-96 Doctorat Mention Biochimie, "Interactions entre les médiateurs lipidiques et la prolactine dans la différenciation de cellules utérines stromales de rat" Université Claude Bernard Lyon I, INSA de Lyon.
    1996 Doctorat en Pharmacie, Université Claude Bernard Lyon I.
    1997-99 Stage post-doctoral dans le laboratoire de Physiologie et Biophysique du Pr. G. Gibori, Université de l’Illinois, Chicago.
    2007 Habilitation à Diriger des Recherches de l’Université de Bourgogne. "Apoptose, inflammation et plasticité cérébrale".

    Research Topics

    Mes travaux de recherche, s'inscrivant dans le domaine des neurosciences, s’intègrent dans le projet de recherche de l’Unité visant à comprendre comment l’activité physique peut induire la plasticité cérébrale dépendante du BDNF (brain-derived neurotrophic factor). Nous avons ainsi montré récemment qu'une partie importante du BDNF présent dans le cerveau correspond au BDNF exprimée par les cellules endothéliales cérébrales et qu'il existe un contrôle des taux cérébrovasculaires de BDNF par le NO produit par les microvaisseaux cérébraux, identifiant le NO et le BDNF d'origine endothéliale comme des cibles innovantes de stratégies capables de stimuler la plasticité cérébrale.


    Physiologie humaine, biologie cellulaire


    Publications depuis 2010

    • Béjot, Y., Prigent-Tessier A., Cachia, C., Giroud, M., Mossiat, C., Bertrand, N., Garnier, P. and Marie C. Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats. Neurochemistry International, 2011, 58, 102-111.


    • Béjot, Y., Mossiat, C., Giroud, M., Prigent-Tessier A., and Marie, C. Circulating and brain BDNF levels in stroke rats. Relevance to clinical studies. PLoS One, 2011, 6, e29405.


    • Quirié, A., Hervieu, M., Garnier, P., Demougeot, C., Mossiat, C., Bertrand, N., Martin, A., Marie, C. and Prigent-Tessier, A. Comparative effect of treadmill exercise on mature BDNF production in control versus stroke rats, PLoS One, 2012, 7, e44218.


    • Madinier, A., Bertrand, N., Rodier, M., Quirié, A., Mossiat, C., Prigent-Tessier, A., Marie, C. and Garnier, P. Ipsilateral versus contralateral post-stroke neuroplastic changes : involvement of BDNF? Neuroscience, 2013, 231, 169-181.


    • Quirié, A., Demougeot, C., Bertrand, N., Mossiat, C., Garnier, P., Marie, C. and Prigent-Tessier, A. Effect of stroke on arginase expression and localization in the rat brain. European Journal of Neuroscience, 2013, 37, 1193-1202.


    • Chouraqui, E., Leon, A., Repesse, Y., Prigent-Tessier, A., Bouhallab, S., Bougle, D., Marie, A., and Duval, D. Deferoxamine blocks the death induced by glutathione depletion in PC 12 cells Neurotoxicology, 2013, 37, 221-230.


    • Prigent-Tessier, A., Quirié, A., Maguin-Gaté, K., Szostak, J., Mossiat, C.,Nappey, M., Devaux, S., Marie, C. and Demougeot, C. Physical training and hypertension have opposite effects on endothelial brain-derived neurotrophic factor expression. Cardiovascular Research, 2013, 100, 374-382.


    • Rodier, M., Prigent-Tessier, A., Bejot, Y., Jacquin, A., Mossiat, C., Marie, C. and Garnier, P. Exogenous t-PA administration increases hippocampal mature BDNF levels. plasmin- or NMDA-dependent mechanism? PloS one, 2014, 9, e92416.


    • Rodier, M., Quirié, A., Prigent-Tessier, A., Béjot, Y., Jacquin, A., Mossiat, C., Marie, C. and Garnier P. Relevance of Post-Stroke Circulating BDNF Levels as a Prognostic Biomarker of Stroke Outcome. Impact of rt-PA Treatment. PloS one, 2015, 10, e0140668.


    • Totoson P., Maguin-Gaté K., Prigent-Tessier A., Monnier A., Verhoeven F., Marie C., Wendling D., Demougeot C. Etanercept improves endothelial function via pleiotopic effects in rat adjuvant-induced arthritis. Rheumatology, 2016, 55, 1308-1317.


    • Banoujaafar H., Monnier A. Pernet, N., Quirié, A., Garnier, P., Prigent-Tessier, A., Marie, C. Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide. European Journal of Neuroscience. 2016, 44, 2226-2235.


    • Monnier, A., Prigent-Tessier, A., Quirié, A., Bertrand, N., Savary, S., Gondcaille, C., Garnier, P., Demougeot, C., Marie, C. Cerebrovascular BDNF : a forgotten nitric oxide-dependent source of BDNF for the brain. Acta physiologica, 2016, doi: 10.1111/apha.12743.


    • Monnier, A., Garnier, P., Quirié, A., Pernet, C., Demougeot, C., Marie, C., Prigent-Tessier, A. Effect of short-term exercise training on brain-derived neurotrophic factor signaling in spontaneously hypertensive rats. Journal of Hypertension, doi: 10.1097/HJH.0000000000001164

    Read more: Anne Tessier

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