Philippe Garnier

Professor

pgarnier@u-bourgogne.fr
+33 3 80 39 34 93
Room N° 375A

UFR des Sciences de Santé, 7 Bd Jeanne d’Arc, 21079 Dijon CEDEX

PROFILE

Biochemistry, molecular biology, neurosciences, BDNF, physical activity, neuroplasticity

1998	Master of biochemistry, cellular and molecular biology. University of Burgundy. “Expression of HSP72 mRNA and protein in response to cerebral ischemia and hypoxia. Impact of blood glucose supply”.
2001	PhD in biochemistry and molecular biology. “Neuronal death, protein expression and glial response in gerbils submitted to transient hypoxia and cerebral ischemia”.
2001	Level 1 in animal experimentation
2002-2004	Post-doctoral position in neurology unit of Pr. R. Swanson. University of California at San Francisco.
2008	HDR (French post-doctoral degree allowing its holder to supervise PhD students). PARP-1 and cerebral ischemia.
2020	Degree in surgery in animal experimentation

My work aims at elucidating neuroplasticity mechanisms with a particular attention to the link between physical activity and brain health improvement with a focus on BDNF produced by cerebral endothelium. Indeed, we have recently showed that the endothelium of brain vessels is a major source of BDNF and this type of cells, similarly to neurons, responds to physical activity by an increase in BDNF production. These findings are in line with the link between cardiovascular and brain health and suggest that endothelial BDNF originating from the brain could have a prominent role in beneficial effects of physical activity by the control of vasomotricity and potentially, neuroplasticity. Of note, we are developing new protocols of electromyostimulation in order to evaluate the pro-neuroplastic potential of this physical activity modality.

Structural biochemistry, metabolism and molecular biology.

PUBLICATIONS

All
2021
2020
2019
2018
2017
2016

Scientific articles in international or national peer-reviewed journals

2021

Pedard M, Quirié A, Tessier A, Garnier P, Totoson P, Demougeot C, Marie C (2021) A reconciling hypothesis centred on brain-derived neurotrophic factor to explain neuropsychiatric manifestations in rheumatoid arthritis. Rheumatology 60(4):1608- (IF : 7,09)

2020

Cefis M, Quirié A, Pernet N, Marie C, Garnier P, Prigent-Tessier A (2020) Brain-Derived Neurotrophic Factor Is a Full Endothelium-Derived Factor in Rats. Vascular Pharmacology 128‑129:106674. (IF : 5.77)

Pedard M, Quirié A, Tessier A, Garnier P, Totoson P, Demougeot C, Marie C (2020) A Reconciling Hypothesis Centered on Brain-Derived Neurotrophic Factor to Explain Neuropsychiatric Manifestations in Rheumatoid Arthritis. Rheumatology 60(4):1608-1619. (IF : 7.58)

2019

Cefis M, Prigent-Tessier A, Quirié A, Pernet N, Marie C, Garnier P (2019) The effect of exercise on memory and BDNF signaling is dependent on intensity. Brain Structure and Function 224(6):1975-1985 (IF : 3,3)

Pedard M, Cefis M, Ennequin G, Quirie A, Garnier P, Prigent-Tessier A, et al. (2019) Brain-derived Neurotrophic Factor Pathway after Downhill and Uphill Training in Rats. Medicine and Scienc in Sports and Exercise. 51:27–34. (IF : 4)

2018

Marie C, Pedard M, Quirié A, Tessier A, Garnier P, Totoson P, Demougeot C (2018) Brain-derived neurotrophic factor secreted by the cerebral endothelium: A new actor of brain function? Journal of Cerebral Blood Flow and Metabolism 38(6):935-949. (IF : 6,04)

Pedard M, Quirie A, Totoson P, Verhoeven F, Garnier P, Tessier A, Demougeot C, Marie C (2018) Corrigendum to “Vascular brain-derived neurotrophic factor pathway in rats with adjuvant-induced arthritis: Effect of anti-rheumatic drugs”.Atherosclerosis 274:77-85 (IF : 4,26)

Pedard M, Quirié A, Garnier P, Tessier A, Demougeot C, Marie C (2018) The cerebral brain-derived neurotrophic factor pathway, either neuronal or endothelial, is impaired in rats with adjuvant-induced arthritis. Connection with endothelial dysfunction. Frontiers in Physiology 8:1125. (IF : 3.2)

2017

Monnier A, Garnier P, Quirie A, et al (2017) Effect of short-term exercise training on brain-derived neurotrophic factor signaling in spontaneously hypertensive rats. Journal of Hypertension 35:279–90. (IF : 4.1)

2016

Banoujaafar H, Monnier A, Pernet N, Quirie A, Garnier P, Prigent-Tessier A, Marie C (2016) Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide. European Journal of Neuroscience 44:2226-2235 (IF : 2.94)