• Study of muscle-brain crosstalk: role of myokines in exercise-induced neuroplasticity
• Study of mechanisms underlying muscle atrophy and weakness developed during aging

Biochemistry, pharmacology and toxicology

Cefis M, Marcangeli V, Hammad R, Granet J, Leduc-Gaudet J-P, Gaudreau P, Trumpff C, Huang H, Picard M, Aubertin-Leheudre M, Bélanger M, Robitaille R, Morais J.A, Gouspillou G. The impact of physical activity on physical performance, mitochondrial bioenergetics, ROS production and calcium handling across the human adult lifespan bioRxiv 2024.07.09.602758; doi: https://doi.org/10.1101/2024.07.09.602758.

Christopher T. A. Lewis, Roger Moreno-Justicia, Lola Savoure, Enrique Calvo, Agata Bak, Jenni Laitila, Robert A.E. Seaborne, Steen Larsen, Hiroyuki Iwamoto, Marina Cefis, Jose A. Morais, Gilles Gouspillou, Jorge Alegre-Cebollada, Thomas J. Hawke, Jesús Vazquez, Miquel Adrover, Vincent Marcangeli, Atul S. Deshmukh, Julien Ochala. Dysregulated Skeletal Muscle Myosin Super-relaxation in Type II, but Not Type I, Diabetes Mellitus. bioRxiv 2024.06.12.598615; doi: https://doi.org/10.1101/2024.06.12.598615

Cefis M.*#, Dargegen M.*, Marcangeli V., Dulac M., Leduc-Gaudet J.P., Mayaki D., Hussain SNA, Gouspillou G#. MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf). 2024 Feb 23:e14119. doi: 10.1111/apha.14119. Epub ahead of print. PMID: 38400630

Cefis M. #, Chaney R., Wirtz J., Méloux A., Quirié A., Léger C., Prigent-Tessier A., Garnier P#. Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction. Front Mol Neurosci. 2023 Oct 5; 16:1275924. doi: 10.3389/fnmol.2023.1275924. PMID: 37868812; PMCID: PMC10585026.

autophagy in skeletal muscles worsens sepsis-induced muscle dysfunction, impairs whole-body metabolism, and decreases survival. iScience. 2023 Jul 25;26(8):107475. doi: 10.1016/j.isci.2023.107475. PMID: 37588163; PMCID: PMC10425945.

Leduc-Gaudet J.P*, Franco-Romero A*, Cefis M, Moamer A, Broering F.E, Milan G, Sartori R, Chaffer T.M, Dulac M, Marcangeli V, Shams A, Mayaki D, Huck L, Morais J.A, Duchesne E, Lochmuller H, Marco Sandri M, Hussain SNA, and Gouspillou G. MYTHO: a novel regulator of skeletal muscle autophagy and integrity. Nat Commun 14, 1199 (2023). https://doi.org/10.1038/s41467-023-36817-1

Hajj-Boutros G., Karelis A.D., Cefis M., Morais J.A., Casgrain J., Sonjak V. Potential Mechanisms Involved in Regulating Muscle Protein Turnover After Acute Exercise: A Brief Review. Front Physiol. 2023 Jan 9; 13:1106425. doi: 10.3389/fphys.2022.1106425. PMID: 36699675; PMCID: PMC9870712.

Cefis M, Chaney R, Quirié A, Santini C, Marie C, Garnier P, Prigent-Tessier A. Endothelial cells are an important source of BDNF in rat skeletal muscle. Scientific Reports. 2022 Jan 10;12(1):311. doi: 10.1038/s41598-021-03740-8.PMID: 35013359

Chaffer T.J., Cefis M., Leduc-Gaudet J.P. Circadian control of skeletal muscle adaptations to exercise. J Physiology 2022 Feb;600(4):723-724. doi: 10.1113/JP282134. Epub 2021 Aug 17.

Dulac M., Leduc-Gaudet J.P., Cefis M., Ayoub M.A, Reynaud O., Shams A, Moamer A, Nery Ferreira M.F, Hussain SNA, Gouspillou G. Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice. J Physiology. 2021 Sep;599(17):4045-4063. doi: 10.1113/JP281752. Epub 2021 Aug 4. PMID: 34269418

Totoson P., Peyronnel C., Quirié A., Pedard M., Cefis M., Bermont L., Prigent-Tessier A, Prati C., Tournier M., Wendling D., Marie C., Demougeot C. Tofacitinib improved peripheral endothelial dysfunction and brain BDNF levels in the rat adjuvant‐induced arthritis model. Fundam Clin Pharmacol. 2022 Apr;36(2):363-374. doi: 10.1111/fcp.12731. Epub 2021 Oct 26. PMID: 34661311

Cefis M., Quirié A., Pernet N., Marie C., Garnier P., Prigent-Tessier A. Brain-derived neurotrophic factor is a full endothelium-derived factor in rats. Vascular Pharmacology. 2020 May-Jun;128-129:106674. doi: 10.1016/j.vph.2020.106674. Epub 2020 Mar 13. PMID: 32179157

Cefis M., Prigent-Tessier A., Quirié A., Pernet N., Marie C., Garnier P. Memory improvement through activation of BDNF pathway is dependent on exercise intensity. Brain Struct Funct. 2019 Jul;224(6):1975-1985. Doi: 10.1007/s00429-019-01889-7.

Pedard M., Cefis M., Ennequin G., Quirié A., Garnier P., Tessier A., Pernet N., and Marie C. Brain-derived neurotrophic factor pathway after downhill and uphill training in rats. Med Sci Sports Exerc. 2019 Jan;51(1):27-34. Doi: 10.1249/MSS.0000000000001771.

Perrier V., Imberdis T., Lafon P.A., Cefis M., Wang Y., Huetter E., Arnaud J.D., Alvarez-Martinez T., Le Guern N., Maquart G., Lagrost L., and Desrumaux C. Plasma cholesterol level determines in vivo prion propagation. J Lipid Res. 2017 Oct;58(10):1950-1961. Doi: 10.1194/jlr.M073718.